Taffix ™

NASAL PROTECTION AGAINST AIRBORNE VIRUSES.

Taffix ™ is legally marketed in Europe (CE- DE/CA09/0760/N18/001) with the following Indication for Use:
TaffiX ™is indicated for use as a protective mechanical barrier against allergens and viruses (e.g., SARS-CoV-2) within the nasal cavity.

Taffix  is approved in Israel (Amar: 33010001) with the following Indication for Use:
Taffix ™ is intended for use to block inhaled viruses and bacteria within the nasal cavity.

General

While the COVID-19 pandemic brought the economy to standstill world-wide, protection of the civil population is critical to overcoming the infection.
The next phase – “Back to Normality” is the primary objective of governments and public health focused organizations. Preventing a “second wave” while returning gradually to normality will necessitate strict preventive measures.

Taffix is a Nasal powder, personal inhaler that blocks viruses from entering the nasal cells.

Taffix  powder creates a unique thin gel over the nasal mucosa which lasts 4-5 hours.
It significantly shields the cells from inhaled viruses through both mechanical and chemical protection.

taffix COVID-19 nasal

COVID-19 (Corona) virus primary route of infection is through airborne droplets that contaminate mainly the nasal mucosa.

Graph nasus pharma taffix

Respiratory viruses and coronaviruses are sensitive to acidic pH. Acidification of the nasal mucosal microenvironment through acidic solution or acidic gel proved to be highly effective in Influenza and Rhinoviruses

Lamarre A, Talbot PJ. Effect of pH and temperature on the infectivity of human coronavirus 229E. Can J Microbiol. 1989;35(10):972–974. doi:10.1139/m89-160

Taffix

Treatment of nasal mucosa in acidic saline reduced viral load within 1 minute in 3 log cycle. Acidified nasal gel reduced viral load in 5 log cycles !!

HPMC – a well-known and safe pharmaceutical
excipient is known to create a thin gel over mucosal
surfaces, and is used in artificial tears (Systain ®) as gel
forming protection and as nasal powder against
allergic rhinitis (Nasaleze ®)

Nasus unique technology creates uniform small
microspheres that create an even thin gel over the nasal
mucosa.

Taffix  – Nasus nasal powder has appropriate acidic environment that blocks viruses effectively within less than one minute and prevents viruses from entering the nasal mucosa.

nasusphrma taffix
Virus nasus pharma taffix

Efficacy of Taffix™

The efficacy of TaffiX – HPMC gel in blocking viral invasion into cells have been researched by Nasus. Our results demonstrated that Taffix  is able to block up to 99% of viruses from infecting cells and thus preventing infection.

Virus nasus pharma taffix

In a series of in vitro studies Nasus tested the efficacy of Taffix™ in preventing viruses from infecting and killing human cells:

Taffix™ Effectively blocks SARS-CoV-2 (COVID-19) from reaching and infecting cells:

1

Blocks SARS-CoV-2

nasusphrma taffix
nasusphrma taffix

2

highly protective

Figure 4: MDCK cell viability – H1N1 influenza virus:

Taffix reduced cell death caused by H1N1 influenza virus by 90%: MDCK cells were treated with H1N1 influenza virus and their viability was tested. Viruses were pretreated by Taffix or saline for 5 minutes or 30 minutes prior to infection. The results show the highly protective effect (90%) of  Taffix in maintaining cell viability.

3

High efficacy

In another study, the efficacy of Taffix was tested in preventing viral invasion into HEK293T cells. In this study, GFP lentivirus was used based on its ability to insert a GFP fluorescent gene into infected cells thus enabling the identification of virus-infected cells.

nasusphrma taffix

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