Intranasal Epinephrine (NS-002)
Access to Epinephrine is a priority for reducing Anaphylaxis. Intranasal Epinephrine aimed at assisting in acute emergency situations.
NS002 Designed to Address the Limitations of Intramuscular Epinephrine
Source: 1. Cantor Fitzgerald Research; Kaplan et al. 2023 AAAAI Annual Meeting; Census.Gov; CDC.Gov; Payroll.Org 2. Cantor Fitzgerald Research; Market Watch; Kaplan et al. 2023 AAAAI Annual Meeting 3. Cantor Fitzgerald Research; Lowenthal et al. 2023 AAAAI Annual Meeting; Asthma and Allergy Foundation of America; Brooks et al. 2017 Ann Allergy Asthma Immunol; Fleming et al. 2015 J Allergy Clin Immunol Pract; McMurty et al. 2015 Clin J Pain
Anaphylactic Shock: A Time-Critical Medical Emergency
- Anaphylaxis is a severe allergic reaction; fatal in ~1% of cases1
- The standard of care for anaphylaxis is Epinephrine – this is typically self-administered via an Epinephrineauto-injector (EAI) or given via intramuscular (IM) injection by a healthcare providerQuick Epinephrine delivery can make the difference between life and death.
Source: 1 Cantor Fitzgerald Research; Reber et al. 2017 J Allergy Clin Immunol; Allergy and Asthma Network; Nguyen et al. 2021 Int J Mol Sci; Munoz-Cano et al. 2017 Front Immunol 2 Emergency treatment of anaphylactic reactions: guidelines for healthcare providers. Resuscitation Council (UK); 2016, 3 JF Philips et al. Allergy Asthma Proc (2011), 4 JT Fleming et al. J Allergy Clin Immunol Pract (2014), 5 E. Andrew et al. Prehospital Emergency Care (2018), 6 Yu RJ et al. J Allergy Clin Immunol Pract. (2021) 7. Source: Clutter WE, Bier DM, Shah SD, Cryer PE. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J Clin Invest.
Phase 2 Study: More Patients Achieved Hemodynamic Therapeutic Threshold of Epinephrine by NS002 Compared to EpiPen at 6 Minutes
Phase 2 PK results
* None of the studies of NS-002 were powered for statistical significance. In trials not powered for statistical significance, there is a high chance that observed effects may not be real due to small sample size.
NS002: Phase 2 Results Summary
NS002 Could Be a Compelling Alternative to Epinephrine Autoinjectors
